Prevalence of carriers of family members of Enterobacteriaceae producing Extended-spectrum β-lactamase in the feces of hospitalized children

Background and Aim : Children are at risk for disease, and this is especially true for those admitted to the NICU. Extended-spectrum β-lactamase-producing enterobacteriaceae are one of the bacterial species that can spread to wards of these hospitalized children. The aim of this study was to evaluate the prevalence of enterobacteriaceae producing Extended-spectrum β-lactamase in the feces of children admitted to the intensive care unit of a pediatric hospital.Methods : In this experimental study, patient's information including age, sex, type of disease, history of hospitalization, duration of hospitalization, etc. was first collected by a questionnaire. The collected stool samples were examined by culture and antibiogram and a drug resistance pattern was determined for them.Results : In this study, fecal samples of ۷۴ patients were examined. ۹۲% of patients in the first culture had at least one of three families of Enterobacteriaceae (۶۹.۴% Escherichia, ۱۸.۱% Klebsiella and ۱۲.۵% Enterobacter). Fifty-nine percent of patients in the first culture and ۵۱.۳% in the second culture were positive for ESBL phenotype. Resistance pattern of ۵۰ patients was studied. ۶۶% had different pattern and the remaining ۳۴% had the same drug resistance pattern in the first and second cultures and the highest frequency was related to CEFOTAXIM-CLAVULANIC ACID (۲۴.۲%).Conclusion : Extended-spectrum β-lactamase-producing enterobacteriaceae have a high prevalence and high antibiotic resistance in the feces of neonates admitted to the NICU care unit. This resistance has correlation with the age and sex and previous antibiotics taking. The ESBL gene can change the degree of antibiotic resistance from susceptible to resistant, even during hospitalization.

کلیدواژه ها:

Enterobacteriaceae ، Extended-spectrum β-lactamase ، pediatric ، drug resistance