Background and Aim :
Urinary tract infection is one of the most important bacterial infections among all ages and sexes. Delays in diagnosis and treatment can cause remarkable complications. So the early diagnosis of symptoms by a physician and also determination of causative urinary tract infection microorganism, and the effective antibiotic choice in a geographical region can help to prescription of the right antibiotics. The goal of the present study was to determine the pattern of
sensitivity and resistance to major antibiotics among
Escherichia coli causing urinary tract infections in Namazi Hospital in Shiraz. Methods : This retrospective cross-sectional studied was performed on ۱۹۱۰ positive urine samples including
Escherichia coli bacteria which was isolated from patients referred to Namazi Hospital in ۲۱۰۸ and ۲۰۱۹.Results : A total of ۱۹۱۰
Escherichia coli strains were isolated, ۶۴% were female, and the rest were male. During these two years, the mean age was ۵۶.۵۷ ± ۲۹.۳۶ for men and ۵۰.۶۵ ± ۲۵.۶۲ for women. Altogether, ۸۶.۹% and ۸۹.۷% of the isolates were resistant to at least one quinolone and cephalosporin antibiotic during the two years of study, respectively. During these two years, the great resistance rate were detected against cephalexin (۸۷.۹%) and nalidixic acid (۸۶.۱%), respectively. Also, the highest susceptibility were observed in the strains to amikacin (۸۸.۳%), nitrofurantoin (۷۶.۸%), and gentamicin (۷۰.۶%), respectively. Incidence of resistance to ciprofloxacin (P-value = ۰.۰۰۴), norfloxacin (P-value = ۰.۰۰۸), tetracycline (P-value = ۰.۰۳۸), cefotaxime (P-value = ۰.۰۱۵) and nitrofurantoin (P-value <۰.۰۰۱) during these two years have increased significantly.Conclusion : In conclusion, the rate of resistance to antibiotics such as ciprofloxacin, norfloxacin, tetracycline, cefotaxime, and nitrofurantoin is increasing, and physicians should consider the antibiotic resistance patterns according to results of antibiogram tests to prescribe the effective antibacterial agents.