Evaluation of antibiotic resistance pattern of Klebsiella pneumoniae isolates, collected from patients in some Tabriz hospitals

Background and Aim : Klebsiella pneumoniae is one of the important clinical pathogens and responsible for some nosocomial infections; especially pneumonia, septicemia, and urinary tract infection (UTI). Multiple drug resistance among Klebsiella pneumoniae isolates is one of the most important challenges for treating of such infections worldwide. The aim of this study was to determine the resistance of Klebsiella pneumoniae isolates collected from Tabriz hospitals.Methods : In this cross-sectional descriptive study, ۱۸۰ gram-negative bacterial isolates obtained from urinary tract infections in Sina, Madani and Al-Zahra hospitals in Tabriz were studied. The selective culture media and biochemical test were used for the identification of Klebsiella pneumonia isolates. Antibacterial susceptibility of isolates was defined to Commonly used antibiotics in the treatment of infections caused by gram-negative bacteria using disk diffusion (Kirby – Bauer) method.Results : Out of ۱۸۰ samples collected from different specimens, ۷۲ isolates of Klebsiella pneumoniae were identified by biochemical tests. The highest antibiotic resistance of Klebsiella pneumoniae isolates to ampicillin with ۱۰۰% and the lowest resistance with ۳۰% to chloramphenicol was observed. ۶۸% of the isolates showed resistance to Extended-Spectrum ?-Lactamase phenotypically.Conclusion : High resistance and multidrug resistance among Klebsiella pneumoniae isolates should be considered as an alarm in all hospital wards. High resistance and multidrug resistance among Klebsiella pneumoniae isolates should be considered as an alarm in all hospital wards. An antibiogram should be done before treating Klebsiella pneumoniae infections with antibiotics.

کلیدواژه ها:

Klebsiella pneumoniae ، Tabriz hospitals