Two years study of prevalence and antibiotic resistance pattern of Gram-negative bacteria isolated from surgical site infections in the North of Iran

Background and Aim : Surgical site infections (SSIs) are a devastating complication of hospitalization and one of the global health problems The present study aimed to investigate the frequency and antibiotic susceptibility pattern of Gram-negative bacteria (GNB) isolated SSIs in the North of Iran.Methods : This cross-sectional study conducted over a two-year period during ۲۰۱۸-۲۰۲۰ on all cases of SSIs who had a positive culture for a GNB. Standard microbiological tests were followed for the bacterial isolation and identification. Antimicrobial susceptibility profiles were determined using disk diffusion method. Results : During the study period, a total of ۷۸ nonduplicated GNB isolated from SSIs. The most prevalent surgical procedures were fracture fixation (۳۷.۲%), and tissue debridement (۲۳.۱%). Klebsiella isolates showed the highest isolation rate (۲۹.۵%) followed by Enterobacter (۲۸.۲%), and Acinetobacter (۱۶.۷%). Antibiotic susceptibility results showed that Acinetobacter isolates were almost resistant to all of the tested antibiotics, except gentamicin, co-trimoxazole, and meropenem. Enterobacteriaceae isolates showed the lowest resistance against amikacin, co-trimoxazole, and imipenem. Overall, ۴۹ (۶۲.۸%) of isolates were multiple drug-resistant (MDR). Conclusion : In summary, a remarkable rate of MDR isolates which showed an increasing trend during recent years is a serious alarm for the management of SSIs caused by GNB. Moreover, the results of regional assessments, provide good epidemiological background for comparing our situation with other regions.

کلیدواژه ها:

Surgical site infection ، Gram-negative bacteria ، Antibiotic resistance ، MDR