Phage therapy; a novel way to prevent antibiotic resistance

Background and Aim : Today, with the increasing use of antibiotics, we are witnessing antibiotic resistance and the treatment of bacterial infections has faced a serious challenge. Phage therapy, the use of bacteriophage viruses in the treatment of bacterial infections can be an effective way to combat antibiotic resistance. The purpose of this study was to review phage therapy; Is a solution to combat antibiotic resistance.Methods : This research is a review. After searching for the keywords phage therapy, antibiotic resistance, drug resistance, microbiology, and using AND and OR variables, from ۲۰۱۵ to ۲۰۲۰, ۶۳ related articles were extracted from Embase, Scopus, and PubMed databases.Results : The findings indicate that this treatment method is being developed and recently has positive results in controlling bacterial infections and is a suitable alternative to antibiotic therapy. Bacteriophages specifically kill the target bacteria and have many applications in killing pathogenic bacteria.Conclusion : Bacteriophages are bacterial viruses that are the most abundant biological species on Earth with several about ۱۰۳۲ and play a vital role in regulating the bacterial population. Recently, phage therapy in the control of bacterial infections is increasing. Bacteriophage can also be considered an excellent antibiotic because it does not cause problems such as drug resistance and has greater drug safety. This treatment is also being developed and requires further research.

کلیدواژه ها:

phage therapy ، antibiotic resistance ، drug resistance ، microbiology