Prevalence of Human Papillomavirus(HPV), Cytomegalovirus(CMV), Epstein-Barrvirus(EBV) and Herpes Simplexvirus(HSV) in human bladder cancer biopsy samples in comparison with the control groups in East Azerbaijan province

Background and Aim : Bladder cancer is one of the most common cancers of the epithelial cells and the second most common cancer of the urogenital tract. The incidence of bladder cancer is higher in men than women. Viral infections are one of the most effective factors in causing cancer. Therefore, the aim of this study was to investigate the prevalence of oncogenic viruses in biopsy samples of patients with bladder cancer in comparison with the control groups in East Azerbaijan province.Methods : ۱۲۰ biopsy samples including ۸۰ samples obtained from patients with bladder cancer and ۴۰ control samples were collected from hospitals of East Azerbaijan province and after deparaffinized, DNA was extracted and using specific primers by PCR method, the frequency of oncogenic viruses was determined.Results : Out of ۸۰ cancer samples, ۲۸ (۳۵%) samples from patients with bladder cancer were infected with HPV virus, ۱۷ (۲۱.۲۵%) samples were infected with CMV virus and ۱۱ (۱۳.۷۵%) samples were infected with EBV virus. In the control group, ۳ samples were infected with HPV, but no positive samples of CMV and EBV were observed in the control group. Two cancer samples were infected with all three HPV, CMV and EBV viruses simultaneously. HSV was not observed in any of the samples. No significant relationship was observed between age group, cancer and oncogenic viruses.Conclusion : Considering the significant presence of oncogenic viruses in bladder cancer compared to the control group, it seems that there is a significant relationship between bladder cancer and viral infection.

کلیدواژه ها:

Bladder cancer ، Human papilloma virus ، Cytomegalovirus ، Epstein-Barr virus ، Herpes simplex virus ، PCR