Fabrication of magnetic polycaprolactone fibers using centrifugal spinning

Nanofibrous constructs containing magnetic nanoparticles have broad application prospects in the biomedical field such as tissue engineering and drug delivery applications. In this work, iron oxide nanoparticles incorporated polycaprolactone (PCL) fibers were fabricated through centrifugal spinning. In this regard, iron oxide nanoparticles were first synthesized by co-precipitation method from the solution of mixed Fe (II)/Fe (III) salts in alkaline medium. The x-ray diffraction (XRD) pattern of samples confirmed the formation of iron oxide phase without impurity with ۱۰.۴۶ nm crystallite size. Field emission scanning electron microscopy (FESEM) images showed that magnetic nanoparticles were sperical with ۲۰ ± ۰.۲۲ nm particle size. Next, PCL was dissolved in different chloroform to dimethyl formaldehyde (DMF) ratio (۵۰:۵۰, ۶۰:۴۰, ۷۰:۳۰ and ۸۰:۲۰) at various concentrations (۱۲, ۱۵, ۱۸ % w/v) and centrifugal spinning was used to fabricate continuous PCL fibers. The results revealed that sample with ۱۸ wt% PCL concentration and ۸۰:۲۰ chloroform to DMF ratio had bead-free continuous fibers. Finally, the magnetic continuous nano fibers, were obtained by dispersion of synthesized iron oxide nanoparticles (۱۰ of polymer w/w %) into the optimized polymer solution using centrifugal spinning technique. FESEM images confirmed the successful fabrication of magnetic fibers and presence of iron oxide nanoparticles within the PCL continuous fibers.

کلیدواژه ها:

iron oxide nanoparticles ، PCL fiber ، Magnetic Nanofiber ، Centrifugal spinning