Effect of intrauterine granulocyte-colony stimulating factor administration on in vitro fertilization outcome in women with moderate -to -severe endometriosis: An RCT
- سال انتشار: 1400
- محل انتشار: مجله طب تولید مثل ایران، دوره: 19، شماره: 8
- کد COI اختصاصی: JR_IJRM-19-8_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 165
نویسندگان
Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
چکیده
Background: Nearly ۲۵-۵۰% of infertile women have endometriosis. There are reports of disorders in the expression of granulocyte colony-stimulating factor (G-CSF) receptors in women with endometriosis. Objective: To examine the effect of intrauterine administration of G-CSF in in vitro fertilization (IVF) cycles on the fertility rate of infertile women with moderate-to-severe endometriosis. Materials and Methods: This clinical trial was conducted on ۶۶ infertile women with moderate-to-severe endometriosis, undergoing IVF and intracytoplasmic sperm injection (ICSI). The participants were allocated into two groups via simple randomization: the G-CSF (n = ۲۷) and control (n = ۳۹) groups. In the G-CSF intervention group, on the oocyte pick-up day, immediately after an ovarian puncture, ۳۰۰ μg of G-CSF was injected through a transcervical catheter under abdominal ultrasound guide to visualize flushing into the uterine cavity. Women in the control group received no intervention. The two groups were evaluated for clinical pregnancy. Results: No significant difference was noted in the demographic characteristics of the two groups. The rate of clinical pregnancy was ۲۸.۲% in the control group and ۲۵.۹% in the G-CSF group, indicating no significant difference (p = ۰.۸۳). Conclusion: The results showed that the intrauterine injection of G-CSF had no effects on pregnancy in women with stage-۳/۴ endometriosis undergoing IVF.کلیدواژه ها
G-CSF, In vitro fertilization, Endometriosis, Pregnancy, عامل تحریک کلنی گرانولوسیت (GCSF), لقاح داخل رحمی آزمایشگاهی, آندومتریوزاطلاعات بیشتر در مورد COI
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