The Association Between ANKRD۵۵ rs۶۸۵۹۲۱۹ SNP and the Risk of Multiple Sclerosis in Iranian Patients
محل انتشار: علوم اعصاب کاسپین، دوره: 7، شماره: 3
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 207
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شناسه ملی سند علمی:
JR_CJNS-7-3_005
تاریخ نمایه سازی: 10 شهریور 1400
چکیده مقاله:
Background: Multiple Sclerosis (MS) is a neuroinflammatory autoimmune disease of the central
nervous system. ANKRD۵۵ rs۶۸۵۹۲۱۹ Single Nucleotide Polymorphisms (SNPs) are reported
as a potential novel MS risk gene, but the biological reasons underlying this correlation are still
mysterious.
Objectives: This study aimed to investigate the potential association of ANKRD۵۵ rs۶۸۵۹۲۱۹ SNP
with the risk of MS in Iranian patients.
Materials & Methods: Blood samples were taken from ۸۰ patients and healthy individuals.
Afterward, the effects of some related-risk factors, such as age, gender, smoking status, drug allergy,
and exposure to chemicals (such as detergents, cleansing chemical, acids, etc., in their common
work area or their daily home exposure) were measured on the incidence of Relapsing-Remitting
MS (RRMS) patients. Polymerase Chain Reaction (PCR) was performed, and the PCR products
were genotyped using the Sanger sequencing system.
Results: The GT genotype of ANKRD۵۵ rs۶۸۵۹۲۱۹ SNP more increased in MS patients than
healthy subjects, and a significant association was found between MS and the rs۶۸۵۹۲۱۹ SNP
in the single-variable association analysis (P=۰.۰۴). In the additive model, our findings indicated
that the rs۶۸۵۹۲۱۹ SNP increased the risk of MS. Additionally, the results of all crude models,
additive, recessive, dominant, and overdominant, were significantly different in participants with
MS compared to the controls.
Conclusion: Eventually, the GT genotype of ANKRD۵۵ rs۶۸۵۹۲۱۹ SNP significantly increased the
risk of MS compared to the TT genotype.
کلیدواژه ها:
نویسندگان
Sepideh Mandegarfard
Department of Biology, Faculty of Engineering, Science & Arts University, Yazd, Iran
Arash Pourgholaminejad
Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Seyed Mohsen Miresmaeili
Department of Molecular and Cellular Biology, Faculty of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran
Seyed Abolhassan Shahzadeh Fazeli
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture and Research, Tehran, Iran.