Pattern of Infection and Antibiotic Activity among Streptococcus agalactiae Isolates from Adults in Mashhad, Iran
- سال انتشار: 1394
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 3، شماره: 2
- کد COI اختصاصی: JR_RBMB-3-2_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 215
نویسندگان
Department of Laboratory Medicine, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Laboratory Medicine, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Laboratory Medicine, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: One of the main causes of sexually transmitted diseases is group B β- hemolytic streptococci (GBS) multiplying in the genital tracts. Penicillin is the most common drug for the treatment of infections caused by these bacteria, but in patients suffering from Penicillin allergy, Erythromycin and Clindamycin are used as alternative therapeutic drugs against GBS. Recently, resistance to these drugs has been reported more often. In this study, efforts have been made to determine the prevalence and antibiotic resistance of GBS. Methods: Modified Christie Atkins Munch-Petersen (CAMP) test was conducted on over ۲۴۰۰ samples of urine and discharge taken from vagina, urethra and prostate. The drug sensitivity was performed by double disk sensitivity tests to Bacitracin, Trimethoprim, and Sulfamethoxazole and then the resistant samples were investigated by E-test to determine the minimal inhibitory concentrations (MICs) value. Results: Twenty-three vaginal and ۱۰ urethral discharge, ۲۷urine and ۶ prostatic secretion samples were GBS positive. The most symbiotic microorganisms with GBS were strains of Enterococci (۹۰%), Staphylococcus saprophyticus (۲۵%) and Candida albicans (۶%). The disk diffusion method showed ۱۸ cases with Penicillin resistance (MIC: ۱.۵ mg/ml). Conclusion: Taken together, GBS carriers’ rate in this study was found ۲۰.۶۵% (۸.۲۴% men and ۱۲.۴% women). Furthermore, findings showed high-level resistance to Erythromycin and Clindamycin.کلیدواژه ها
Antibiotic resistance, Genitourinary system, Minimal inhibitory concentration (MIC), Streptococcus agalactiaeاطلاعات بیشتر در مورد COI
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