GATA۳ Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population

Background:  The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA۳ single nucleotide polymorphisms and AR in an Iranian population was identified. Methods:  This case-control study was performed on ۸۶ patients with AR and ۸۶ healthy subjects. This study aimed to evaluate a potential association between two GATA۳ SNPs, rs۱۲۶۹۴۸۶ and rs۲۲۲۹۳۶۰, and AR. Blood samples were collected and DNA was extracted for the evaluation of these SNPs by RFLP-PCR. Results: A statistically-significant association was found between rs۱۲۶۹۴۸۶ and AR (P<۰.۰۰۱). The frequencies of the A and GA genotypes were less in patients than in controls. The frequencies of the G allele and the GG genotype were greater in patients than in controls (P < ۰.۰۰۱). Conclusions: SNP rs۱۲۶۹۴۸۶ of GATA۳ was associated with AR and sensitivity to aeroallergens in our population. Because of the significance of this gene in AR, studying the association between GATA۳ polymorphisms and AR is recommended for other populations.

کلیدواژه ها:

Allergic rhinitis ، GATA۳ ، Genetic ، SNP