Common Variations in Perilipin rs۱۰۵۲۷۰۰ and FTO rs۳۷۵۱۸۱۲ Genes, Central Obesity, and Risk Type-۲ Diabetes
- سال انتشار: 1396
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 6، شماره: 1
- کد COI اختصاصی: JR_RBMB-6-1_011
- زبان مقاله: انگلیسی
- تعداد مشاهده: 175
نویسندگان
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Biology, Zabol University, Zabol, Iran
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده
Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-۲ diabetes (T۲D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T۲D was investigated. Methods: Clinical traits in a random sample of ۱۸۳ Iranian men and women with T۲D and ۱۷۴ controls without any metabolic disease took part in the study. The sample was genotyped using Tetra-ARMS method. Results: In Perilipin (rs۱۰۵۲۷۰۰) polymorphism tested, a significant association was found between this polymorphism and T۲D (P=۰.۰۳). In FTO (rs۳۷۵۱۸۱۲) polymorphism, a significant association was seen between this gene and obesity (P=۰.۰۰۳). But, no significant relation was found between this genotype and T۲D. Conclusion: The rs۳۷۵۱۸۱۲ polymorphism of FTO gene is the major genetic determinant of obesity, but not type-۲ diabetes. The rs۱۰۵۲۷۰۰ polymorphism of Perilipin gene is related to T۲D but not obesity.کلیدواژه ها
Type-۲ diabetes, FTO, Perilipin, gene polymorphismاطلاعات بیشتر در مورد COI
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