An In vitro Study on Curcumin Delivery by Nano-Micelles for Esophageal Squamous Cell Carcinoma (KYSE-۳۰)

  • سال انتشار: 1397
  • محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 6، شماره: 2
  • کد COI اختصاصی: JR_RBMB-6-2_004
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 355
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نویسندگان

Sare Hosseini

Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Jamshidkhan Chamani

Department of Biology, Faculty of Sciences, Islamic Azad University-Mashhad Branch, Mashhad, Iran.

Hamidreza Rahimi

Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Navid Azmoodeh

Department of Biology, Faculty of Sciences, Islamic Azad University-Mashhad Branch, Mashhad, Iran.

Faezeh Ghasemi

Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Porya Hassan Abadi

School of Medicine, University of Birmingham, Birmingham, UK.

چکیده

Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcuminchr('۳۹')s bioavailability. Cyclin D۱ is overexpressed in ESCC and curcumin may change its expression. Methods: In this study, the effect of SinaCurcumin®, a novel nano-micelle product containing ۸۰ mg curcumin, on the growth of KYSE-۳۰ cells and expression of cyclin D۱, was investigated. Paclitaxel and Carboplatin served as reference drugs. Results: Nano-curcumin increased cell cytotoxicity, decreased IC۵۰, and down-regulated of cyclin D۱. However, treatment of cells with nano-curcumin might result in multidrug resistance. Conclusions: Nano-curcumin suppressed proliferation of KYSE-۳۰ cells and expression of cyclin D۱ although its use in combination with other chemotherapeutic agents requires further testing.

کلیدواژه ها

Curcumin, Cyclin D۱ gene, Drug resistance, KYSE-۳۰ cells, Nano-Micelle

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