Burden of Alzheimer's disease and other dementias in elderly people in Asia: a systematic analysis for the Global Burden of Disease Study in ۲۰۱۹

Background and Objective: Alzheimer's disease (AD) is a progressive and damaging brain disease of unknown etiology. The goal of this study is to investigate the burden of AD in Asia in ۲۰۱۹.Materials and Methods: All data sources accessible from the ۲۰۱۹ Global Burden of Disease study were used to estimate prevalence, mortality and disability-adjusted life years of the Alzheimer's disease and other dementias as well as Alzheimer's disease’s attributable risk factors in Asia from ۱۹۹۰ to ۲۰۱۹. We estimated all-cause and cause-specific mortality, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs) and attributable risks. All estimates were presented as counts and age-standardized rates per ۱۰۰,۰۰۰ population with uncertainty intervals (UIs).Findings: The highest incidence, prevalence, mortality, burden of disease, YLL and YLD belonged to high-income areas and the lowest to middle-income areas. There is a positive and significant correlation between human development index (HDI) and disease incidence (r = ۰.۳۱۹, P<۰.۰۵) and the prevalence of the disease (r=۰.۳۲۵, P <۰.۰۵). The results revealed a positive and significant correlation between HDI and disease burden (DALY) in women (r = ۰.۳۲۵, P <۰.۰۵). There is also a positive and significant correlation between HDI and YLD in both sexes (r = ۰.۴۱۴, P <۰.۰۵). However, no positive and significant correlation was found between HDI and YLL (P> ۰.۰۵). There incidence of AD in the elderly was positively and significantly related to the mean years of schooling (r = ۰.۴۲۸, P <۰.۰۵). Also, life expectancy at birth was positively and significantly correlated with the burden of disease (DALY) (r = ۰.۳۶۲, P <۰.۰۵) and YLL (r = ۰.۳۱۷, P <۰.۰۵). The results also illustrated a positive and significant correlation between YLD and mean years of schooling (r = ۰.۵۱۰, P <۰.۰۵) life expectancy at birth (r = ۰.۳۹۷, P <۰.۰۵) and expected years of schooling (r = ۰.۳۹۹, P <۰.۰۵).Conclusion: These estimates can be used to guide the elderly care planning and interventions. Hence, policymakers and health care providers need to be informed of these trends to provide appropriate services.

کلیدواژه ها:

Dementia ، Alzheimer’s disease ، Burden disease ، DALY ، Elderly