Zahra Ghavidel - MSc of Cellular-Molecular Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran
Zahra Samadi - MSc of Cellular-Molecular Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran
Toktam Hajjar - Faculty member at the Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran
Madjid Momeni-Moghadam - Faculty member at the Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran
Eisa Kohan-Baghkheirati - Faculty member at the Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran

Breast cancer is a major cause of cancer death among women around the world . Surgery, radiation and chemotherapy are commonly used to treat breast cancer along with hormone therapy. Despite of major advances in the control and treatment of breast cancer, side effects and ineffectiveness of existing methods lead to identification and use compounds of medicinal plants. Hence, the anticancer effects of Falcaria vulgaris extract on growth of ectopic breast cancer in balb-c mice was evaluated. Ectopic breast tumor was induced by injection of ۴T۱ cell line in both treatment and control balb-c mice. The treatment group was received Falcaria vulgaris hydroalcoholic extract ۱۰ times in a period of ۲۰ days. Tumor mass volume was measured during the treatment period and after the sacrifice of mice. Analysis of results with Repeated ANOVA test showed that Falcaria vulgaris extract prevented the increase of tumor volume during the period in the treatment group compared to the control group, significantly (P <۰.۰۵). These results indicate that Falcaria vulgaris extract has anti-cancer effects on the growth of ectopic breast tumor mass in the balb-c mice. This effect can be due to the anti-cancer compounds of Falcaria vulgaris extract. The isolation and identification of those metabolites could be employed as a suitable treatment in the control of breast cancer growth.

Falcaria vulgaris, balb-c mice, breast cancer, ۴T۱ cell line