Investigation of hydro alcohol extract of Polygonum Bistorta plant on coagulation tests

Hemophilia is an inherited disease caused by a disorder of blood factors, which are proteins needed for blood to clot, in the absence of these proteins, the blood does not clot and bleeding will continue. The aim of this study was investigation of Polygonum Bistorta root extract on bleeding.in this method first, the hydro alcoholic extract of Polygonum Bistorta plant was prepared and the mice were randomly divided into ۳ groups with three doses of ۱۵۰,۲۰۰ and ۳۰۰ mg/kg and a control group. The extract was gavage to mice daily and on day ۱۴, blood samples were taken from the mice and the collected blood was examined for PT (Prothrombin time) and aPTT (Activated partial Thromboplastin time) tests. This tests acutely show how blood clots in the coagulation pathway. The results of PT and APTT tests showed that coagulation time in Polygonum Bistorta treated mice was less than control mice in all three doses and the ۳۰۰ mg/kg dose had the lowest value among the other two doses. Since PT and APTT study coagulation factors in the external and internal pathway of coagulation cascade, respectively, so this plant can affect both coagulation pathways.

کلیدواژه ها:

Polygonum Bistorta ، Hemophilia ، Medicine traditional ، PT ، APTT