Association study of TBX۲۱ gene polymorphism rs۴۱۵۱۵۷۴۴ with Alzheimer's Disease

Alzheimer’s disease (AD) is the most prevalent neurodegenerative cause of dementia and is responsible for significant individual mortality, and has economic impact on the health care system of populations. It is characterized by progressive cognitive and functional impairment and memory loss. Pathologically, there is formation of amyloid plaques and neurofibrillary tangles in the brain, as well as neuronal loss, synaptic loss, brain atrophy, and inflammation. Accumulation of the amyloid-β (Aβ) peptide, the major component of amyloid plaques, is hypothesized to initiate a pathogenic cascade that eventually leads to AD.T-box expressed in T cells (T-bet), a member of the T-box family of transcription factor genes, was first identified from a Th۱-cell cDNA library as a Th۱-specific transcription factor, and was also cloned as TBX۲۱. The aim of this study is to explore whether TBX۲۱ gene polymorphism rs۴۱۵۱۵۷۴۴ are associated with Alzheimer's disease by T-ARMS-PCR and Graph pad Prism methods. Significant difference in genotype frequencies between patients and controls (p=۰.۰۳) was observed and the frequency of TT genotype was significantly increased in the patient group (۲.۰۱±۰.۰۳) compared to the control group (۱.۰۸±۰.۰۱). So results suggests that (C/T) of (rs۴۱۵۱۵۷۴۴) of TBX۲۱ gene polymorphism might be associated with AD occurrence.

کلیدواژه ها:

Neurodegenerative Disease ، Single Nucleotide Polymorphism ، Inflammation