Benzodiazepine Toxicity Treatment: A Comparative Molecular Docking study of flumazenil and diazepam

Epilepsy is a set of chronic or long-term neurological disorders characterized by an epileptic seizure. Epilepsy is one of the most common neurological diseases in Iran and its prevalence is higher than the world standard. Scientific studies show that about one to one and a half percent of Iranians have epilepsy, which indicates that epileptic patients in Iran are about three times more than in Europe. Flumazenil is a benzodiazepine antidote and is used to treat benzodiazepine poisoning, but studies show that people who take the drug have an increased risk of seizures, a symptom of epilepsy. Different concentrations of diazepam and flumazenil were injected into mice at different intervals to obtain the effective dose and effective time of action of each drug. In this study, it is demonstrated that a concentration of ۰.۷۵ mg / kg of flumazenil can decrease the threshold of induced seizures with PTZ to control value. But concentrations higher than this value reduce the threshold for induction of seizures more than control group and therefore reduce the dose of PTZ.The molecular docking studies identify the binding site of these two drugs on the GABA receptor and show that flumazenil can act as an inhibitor at a site close to the diazepam binding site and neutralize its action.

کلیدواژه ها:

Seizure ، Pentylenetetrazol ، Auto dock Vina