Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography

  • سال انتشار: 1400
  • محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 11، شماره: 5
  • کد COI اختصاصی: JR_AJP-11-5_009
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 329
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نویسندگان

Kobra Soheilipur

Faculty of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran

Mohammad Reza Khazdair

Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Seyyed Ali Moezi

Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Gholamhossein Mahmoudirad

Faculty of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran

چکیده

Objective: Coronary artery disease (CAD) is among the most prevalent diseases in the world, and its severity is usually assessed through coronary angiography (CA). Anxiety is the most prevalent problem before angiography. The aim of this study was to evaluate Crocus sativus (saffron) and Lippia citriodora Kunth (lippia) extracts and saffron-lippia extract combination on anxiety among the candidates for CA. Materials and Methods: This double-blind randomized placebo-controlled trial in four month was conducted on ۱۲۰ angiography candidates in Valiasr hospital, Birjand, Iran. The random allocation was doing through block randomization to saffron, lippia, saffron-lippia, and placebo groups; four hours before angiography, participants in these groups respectively received a single dose of saffron extract capsule (۴۰ mg), lippia extract capsule (۴۰ mg), saffron-lippia extract capsule (۲۰ mg saffron and ۲۰ mg lippia), and lactulose capsule (۴۰ mg). Participants’ anxiety was assessed before, thirty minutes after, and three hours after the intervention via Spielberger State-Trait Anxiety Inventory. Results: The mean scores of state, trait, and total anxiety in the saffron group reduced significantly (p < ۰.۰۵), while the mean scores in the other groups did not change significantly, except for the mean score of trait anxiety in the saffron-lippia group which decreased significantly (p=۰.۰۵). Therefore, after the intervention, the mean scores of state, trait, and total anxiety in the saffron group were significantly lower than the other groups (all, p < ۰.۰۵). Conclusion: This study suggests that the oral use of a single-dose of ۴۰ mg saffron extract is effective in alleviating anxiety among the candidates for CA.

کلیدواژه ها

Coronary Angiography, Anxiety, Saffron, Lippia citriodora, Crocus sativus

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