Majid Ghayour Mobarhan - International UNESCO center for Health Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Saberi-Karimian - International UNESCO center for Health Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Hamideh Qazizadeh - International UNESCO center for Health Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Elham Mohammadzadeh - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Gordon A. Ferns - Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN۱ ۹PH, UK
Amir hosein Sahebkar - Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Objective: Sleep-duration is related to obesity. Curcumin can affect behavioral changes that arise from sleep deprivation in animal models. In this study, we assessed the effects of curcumin on sleep-duration in metabolic-syndrome (MetS) patients. Materials and Methods: This study was a double-blind clinical trial in ۱۲۰ adults with MetS. All participants received crude curcuminoids in a simple formulation (n=۴۰), phospholipidated curcuminoids (n=۴۰) or placebo (n=۴۰) ۱ g/day during ۶ weeks. Demographic data, anthropometric indices and serumbiochemical factors were documented forall volunteers at baseline and after the intervention. A standard questionnaire was used for evaluating physical-activity-level (PAL) and patients’ sleep-duration, including night time sleep and daily napping. Based on the time of sleep, sleeping hours were classified into: night time sleep; daily naps and total sleeping hours in ۲۴ hours. Results: A total of ۱۲۰ participants aged ۳۸.۷۲±۱۰.۰۵ years old were enrolled into the study. We did not find significant differences in biochemical factors, sleep-duration or PAL at baseline among the ۳ groups (p>۰·۰۵). Moreover,curcumin did not exert any significant effect on sleep-duration before, or after, adjustment for confounding factors in the overweight and obese individuals, or in total population (p>۰.۰۵). Conclusion: The results showed that curcumin does not have an effect on sleep-duration in subject with MetS.

Curcumin, metabolic syndrome, sleep duration