Antimicrobial activity of turmeric aqueous extract and chitosan

Background and Aim : Turmeric and chitosan are natural-derived compounds. The present study investigates the antimicrobial and anti-biofilm potentials of turmeric extracts and chitosan against for multiple drug-resistantbacteria.Methods : A group of isolated bacteria from clinical samples with resistance to most of antibiotics were collected by phenotypic and genotypic assays. The minimum inhibitory concentration of turmeric aqueous extract and chitosan investigate with the broth micro-dilution methods. The checkerboard assay used to investigate the synergistic effect of the combination of these natural compounds.Results : The turmeric and chitosan showed inhibitory effect on bacteria, especially on the planktonic form of bacteria. The antibiofilm effect of turmeric and chitosan were more found in isolates.Conclusion : The combination of turmeric and chitosan on the tested bacteria has a synergistic effect. Therefore, turmeric and chitosan can be used in pharmaceutical and disinfectants formulations. The aqueous extract and chitosan fiber will help to produce value added handicrafts.

کلیدواژه ها:

turmeric aqueous ، chitosan ، drug-resistantbacteria