COVID۱۹: Interaction between virus spikes and cell receptor

سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 250

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شناسه ملی سند علمی:

MEDISM21_229

تاریخ نمایه سازی: 23 مرداد 1400

چکیده مقاله:

Background and Aim : Understanding and recognition the viral structure of COVID-۱۹ can help us to design vaccines and drugs for controlling and preventing this new acute respiratory syndrome. The attachment step in viral life cycle occurs when virus enters to body and penetrate into target cells. In this systematic review we want to explain how it will be occurred.Methods : In this systematic review we collected all data information by searching in NCBI and PubMed Central (PMC) and we use search engines like as: Science Direct, MEDLINE and ISI Web of Science. These Data were gathered from full- length articles.Results : SARS-CoV-۲ infects the host using the angiotensin converting enzyme (ACE۲) receptor, which is expressed in several organs, including the lung, heart, kidney, Corona virus entry into target cells by its surface spike named "S" Protein. S protein is a type ۱ glycoprotein that consists of S۱ and S۲ subunits and is present on the virion surface as a trimer. The S۱ region is involved in receptor binding and contains N and C-terminal domains( S۱-NTD and S۱-CTD)respectively that may both act as receptor-binding domain (RBD),with the major determinants of cell tropism residing in S۱-CTD. . the COVID-۱۹ also might interact with some of the previously known host targets like as: CD۲۶, Ezrin, Cyclophilins.Conclusion : Our knowledge about the life cycle and pathogenicity of COVID-۱۹ are increased. Recognition All steps in virus replication can help us to controlling of this epidemic disease.

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نویسندگان

Mina Owrang

Faculty of medicine, Sari branch, Islamic Azad University, Sari, Iran