Biochemical, Hematological and Immunological elements changing in non-hospitalized people in Tehran through Covid-۲۰۱۹

Background and Aim : COVID-۱۹ as a novel strain of Coronaviruses family that are known to cause colds and more serious diseases was discovered in ۲۰۱۹ and has never been found in humans before. Respiratory symptoms, fever, cough, shortness of breath, and dyspnea in infected person with COVID-۱۹ observed. There is currently no specific treatment for COVID-۱۹, therefore infection can cause pneumonia, severe acute respiratory syndrome, kidney failure, and even death. Thereby, there is need rapid and accurate diagnostic tests for screening of suspected persons. This study is aimed to evaluate the clinical significance of Biochemical, Hematological, Serological and antibodies for the highly suspected COVID-۱۹ infection persons.Methods : ۲۳۵ samples of suspected person collected from ۳ labratories in Tehran and clinical tests done with Pars Azmon Kit and Hematological parameters assayed with Mindray BC-۳۰۰۰and CRP were detected by Generic Assay kit. COVID-۱۹ IgG and IgM were detected with Pishtaz Teb Kit (ELISA). Data analyzed by SPSS software v.۱۹.Results : Among ۲۳۵ persons who detected for Covid-۱۹ antibodies and clinical tests, ۱۶ persons had positive and ۳ ones had borderline result. ۱۴ ones were positive for IgG and ۱ ones were IgM positive. ۲ ones were positive for IgM+IgG together and ۳ ones were borderline for IgM. ۵ ones of these persons had history of cough, fever and Shortness of breath (asthma). ۲۲ persons had N/L ratio under ۱.۳ those ۵ ones were antibodies positive that ۱person was IgG+IgM positive, ۳ ones were IgG positive and ۱person was IgM positive. Significance association between N/L ratio with antibodies observed (P value for IgG <۰۳ and for IgM<۰۵ with CI:۹۵).Conclusion : Regards to this study, CRP and other biochemical tests cannot be reliable for screening of suspected persons but CBC test as a first line of diagnostic test can be reliable for screening and also can confirm immunological results for suspected patients.

کلیدواژه ها:

Covid-۱۹ ، Coronavirus ، IgG ، IgM ، Biochemical ، Hematological