Pseudomonas aeruginosa isolated from patients with cystic fibrosis: A systematic review and meta-analysis

Background and Aim : Pseudomonas aeruginosa is an opportunistic pathogen that can form biofilms in the lungs and airways of cystic fibrosis (CF) patients. Increasing rates of resistant and multidrug-resistant (MDR) P. aeruginosa in hospitalized patients constitute a major public health threat.Methods : Data sources of this study were ۵۲ original articles (۲۰۰۰-۲۰۱۹) that were published in the literatures in several databases including PubMed, Science Direct, Google Scholar, Biological abstracts and ISI web of knowledge. Data were analyzed using meta-analysis and random effects models with the software package Meta R, Version ۲.۱۳ (P < ۰.۱۰) (confidence interval: ۹۵%).Results : Out of ۱۱۰ searched articles, ۵۲ were selected. The most common definition of MDR was resistance to more than one agent in three or more categories of antibiotics. Finally, out of ۲۳۴۰۴۸۶ samples, ۲۳.۸۳% of the strains were present in ۵۲ studies of MDR. The highest prevalence of cystic fibrosis due to Pseudomonas was higher in men than in women and ۴۰,۱۳۰. Most of the searched articles were related to the continent and the United States with ۲۶ and ۲۱ items, respectively. Most of the tests used were MIC and PCR. Also, the most searched type of cross-sectional study was with ۲۷ cases.Conclusion : Hospitalized patients with resistant and MDR P. aeruginosa infections appear to have increased all-cause mortality and LOS. The initial empirical treatment of these patients remains challenging because of the strikingly high prevalence of antimicrobial resistance.

کلیدواژه ها:

Cystic fibrosis ، Pseudomonas aeruginosa ، Multidrug-resistant (MDR)