Anti-Novel Coronaviral Herbal Extract As Supportive Medication Strategy

Background and Aim : The novel Coronavirus disease, in comparison with SARS and MERS, has spread more quickly, due to the adaptation of the virus in every environment. Although various drugs are being developed, treatments perform as supportive care which depends on the severity of the illness. Accordingly, limiting the SARS-CoV-۲- severely infected patients will significantly diminish the strain on the healthcare system of the country.Methods : In this plan, we have provided a list of ۱۰ effective herbal compounds against coronavirus, and their chemical construction was achieved using the PubChem database. The compounds were configuration by ChemSketch software. Accordingly, the crystal construction of the Coronavirus virus spike protein S۲ receptor was achieved from the PDB protein database (۷BZ۵). Energy level optimization was Also done using SPDBV software. The protein-ligand docking procedure was defined by PyRx software and the designed algorithm was executed with Cygwin software. Eventually, the information obtained from the file was investigated.Results : A review of ۱۰ anti-nCornonaviral compounds revealed positive and inconclusive results about the efficacy of treatment, using herbal medicine as an adjuvant. Amid examined compounds, Triterpenoid was selected as the most suitable compound with a binding energy of about ۱۱ KJ / mol with an active site and binding energy of -۵ / ۹۴ of total protein blind docking.Conclusion : Through this study, we advise medicinal plants as possible effective and alternative therapeutic procedures by exclusively targeting SARS-CoV-۲ and its pathways.

کلیدواژه ها:

ACE۲ ، SARS-CoV-۲ ، Herbal Extract ، Spike Protein