Investigation of the antibacterial function of liposome containing aloe vera extract by Mozaffari method
محل انتشار: بیست و یکمین کنگره بین المللی میکروب شناسی ایران
سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 203
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شناسه ملی سند علمی:
MEDISM21_193
تاریخ نمایه سازی: 23 مرداد 1400
چکیده مقاله:
Background and Aim : The aim of this study was to investigate the antibacterial function of liposomes containing aloe vera extract. For this purpose, liposomes containing aloe vera extract have been synthesized for optimal use against Staphylococcus aureus and Escherichia coli.Methods : The type of study is laboratory research. The nanoparticle synthesis method is Mozaffari method. Particle characterization has been performed in terms of size and charge with a DLS device and morphology with an atomic energy microscope (AFM) and the amount of loading and release with a spectrophotometer. MIC tests were then performed to evaluate the performance of nanoparticles containing aloe vera extract on Staphylococcus aureus and Escherichia coli.Results : The mean particle diameter was ۶۹ nm and its zeta potential was ۱۶ mV. The loading rate in nanoparticles was ۵۴%, which was calculated by reading the absorption of light from the standard Zanian curve. The minimum inhibitory concentration (MIC) of Staphylococcus aureus and Escherichia coli for nanoparticles was ۶۲.۵ and ۱۲۵ mg / ml.Conclusion : Nanoparticles containing aloe vera extract kill the bacterial bacteria Staphylococcus aureus and Escherichia coli and can be used as antibacterial nanosystems.
کلیدواژه ها:
نویسندگان
Amirhossein Kheirkhah
Department of Medical Biotechnology, School of medical, Shahid Sadoghi University of Medical Sciences, Yazd, Iran
Mohammad Javad Forouzani-Moghaddam
Department of food microbiology, School of Paramedical, Iran University of Medical Sciences, Tehran, Iran
Nazanin Zare
Department of Medical Biotechnology, School of medical, Shahid Sadoghi University of Medical Sciences, Yazd, Iran