A Systematic Review of Gut Microbiota Roles in Irritable Bowel Syndrome
- سال انتشار: 1399
- محل انتشار: بیست و یکمین کنگره بین المللی میکروب شناسی ایران
- کد COI اختصاصی: MEDISM21_167
- زبان مقاله: انگلیسی
- تعداد مشاهده: 326
نویسندگان
PhD student of Medical Bacteriology, Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
PhD candidate of Medical Bacteriology, Department of Pathobiology, School of Public Health, Tehran University of Medical Science, Tehran, Iran
PhD student of Medical Bacteriology, Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran, Student Research Committee, Pasteur Institute of Iran, Tehran, Iran
چکیده
Background and Aim : Irritable bowel syndrome (IBS) is common but difficult to treat. Altering the gut microbiota has been proposed as a strategy for treatment of IBS, but the association between the gut microbiome and IBS symptoms has not been well established. We performed a systematic review to explore evidence for this association.Methods : We searched databases, including MEDLINE, EMBASE, Cochrane CDSR, and CENTRAL, through January, ۲۰۱۸ for case–control studies comparing the fecal or colon microbiomes of adult or pediatric patients with IBS with microbiomes of healthy individuals (controls). The primary outcome was differences in specific gut microbes between patients with IBS and controls.Results : The search identified ۲۶۳۱ citations; ۲۴ studies from ۲۲ articles were included. Most studies evaluated adults presenting with various IBS subtypes. Family Enterobacteriaceae (phylum Proteobacteria), family Lactobacillaceae, and genus Bacteroides were increased in patients with IBS compared with controls, whereas uncultured Clostridiales I, genus Faecalibacterium (including Faecalibacterium prausnitzii), and genus Bifidobacterium were decreased in patients with IBS. The diversity of the microbiota was either decreased or not different in IBS patients compared with controls. More than ۴۰% of included studies did not state whether cases and controls were comparable (did not describe sex and/or age characteristics).Conclusion : In a systematic review, we identified specific bacteria associated with microbiomes of patients with IBS vs controls. Studies are needed to determine whether these microbes are a product or cause of IBS.کلیدواژه ها
Inflammation; Intestine; Comparison; Infectionاطلاعات بیشتر در مورد COI
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