Evaluation of protease activity, gelatinase production and hemolytic in Acinetobacter baumannii isolates

Background and Aim : Acinetobacter baumannii causes a extensive range of infections that due to its adaptability to conditions and organism's survival, presence of different virulence factors and capacity to transmission in nosocomial environment, it has made treatment difficult.Methods : ۷۰ clinical isolates Acinetobacter baumannii were collected during January through May ۲۰۱۹ from three hospitals in Northwest, Iran. The isolates were identified using biochemical tests. The disk diffusion method for eight antibiotics and as well as the MIC for colistin was used. Gelatinase, protease and hemolytic activities were done by the phenotypic methods.Results : The rate of XDR and MDR were ۵۸.۵% and ۱۰۰%, respectively. Moreover, ۹ (۱۲.۸%) isolates were resistant to colistin. The results showed twenty seven (۳۸.۵%) of the isolates of gelatinase activity were positive. hemolytic activity was detected in ۱۱ isolates (۱۵.۵%), while ۳۲ (۴۵.۷%) isolates production of protease.Conclusion : Various virulence factors play a role in causing infections. Knowing the factors that play a role in the development of this organism is effective in preventing infection and treatment

کلیدواژه ها:

Acinetobacter baumannii ، Hemolytic ، Gelatinases ، Protease