Nasal Carriage of Multidrug Resistant Staphylococcus aureus Among Health care workers in Kashan, Iran

Background and Aim : Nasal carriage of Staphylococcus aureus is a substantial source of human infections. Detection and treatment of nasal carriage in children with methicillin-resistant and multidrug resistant S. aureus (MRSA and MDRSA, respectively) may be an important modality in prevention of infections. This study determined the prevalence, antibiotic resistance patterns and risk factors for nasal carriage of MDRSA among health care workers.Methods : This cross-sectional study was carried out on ۳۵۰ health care workers in Kashan city, Iran. From all health-care centers, four were chosen by simple random sampling. Nasal samples were cultured in blood agar medium for S. aureus and antibiotic susceptibility profile was determined by disc diffusion and E-test. Risk factors for nasal carriage of MDRSA were also determined.Results : A total of ۹۲ (۲۶.۳%) S. aureus isolates were obtained, of which ۳۳ (۳۵.۹%) were MRSA and ۲۷ (۲۹.۳%) were MDRSA. Of MRSA strains, ۱۹ (۷۰.۴%) were MDRSA. S. aureus isolates showed ۵۲.۲% resistance to cephalothin, ۳۳.۷% to co-trimoxazole, ۲۶.۱% to clindamycin, ۲۶.۱% to ciprofloxacin, ۴.۳% to vancomycin, and ۳۵.۹% to oxacillin. The risk factors for nasal carriage of MDRSA were antibiotic usage during the last three months (P = ۰.۰۰۶) and emergency parts workers (P = ۰.۰۴۴).Conclusion : MDRSA was not uncommon among health care workers in Kashan and prevention of its spread in the population is judicious.

کلیدواژه ها:

Staphylococcus aureus ، Multidrug Resistance ، Nasal ، Carriers ، Healthy workers