Investigation of Drug Resistance, Presence of ompA and Oxacillinases Genes in Acinetobacter baumannii Isolated from Guilan Hospitals

Background and Aim : Acinetobacter baumannii is one of the most important emerging multi drug-resistant bacteria. Several factors are involved in resistance to the drug and its pathogenicity. Of these factors, OmpA and Oxacillinases genes play an important role. The aim of this study was to assess resistance to drugs and also ompA and Oxacillinases genes existence in A. baumannii isolated from clinical sources from Guilan hospitals.Methods : Clinical samples were collected from clinical sources of Guilan hospitals during the ۲۰۱۷-۲۰۱۸ and the final confirmation were done by using biochemical methods. Then, susceptibilities to antibiotics of different classes were determined by the disc diffusion method, and the presence of ompA and Oxacillinases genes were checked by using the PCR method.Results : The results show that of ۱۵۰ clinical samples, ۴۰ (۲۶.۶۶%) of isolates were formed of A. baumannii and mostly showed resistance to different classes of antibiotics. ۸۴.۹۵% of isolates were Multi Drug Resistance (MDR) and ۷۹.۵۳% were Extremely Drug Resistance (XDR). All of them contained ompA and ۸۰% contained Oxacillinases genes.Conclusion : The presence of multidrug resistance in most isolates, as well as the existence of ompA in all and Oxacillinases genes in ۸۰% samples, can cause bacterial virulence and drug resistance. It seems essential to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii.

کلیدواژه ها:

Acinetobacter baumannii ، Multi Drug Resistance ، ompA and Oxacillinases genes