Antimicrobial Effect of Au Nanoparticle against Streptococcus mutans and Candida albicans biofilms on Denture Stomatitis

Background and Aim : Background: Denture stomatitis (DS) is an oral biofilm–associated inflammation of the denture-bearing mucosa. DS has been reported in ۱۰–۷۰% of complete denture wearers. It is more common on the palatal mucosa. In past decades, research has focused on newer targeted agents with the aim of decreasing the rates of side effects of current antimicrobial. Nowadays the field of nanotechnology becomes one of the most topics of interest. The aim of this study was to evaluate the antimicrobial efficacy of gold nanoparticle (Au-NP) against Streptococcus mutans and Candida albicans biofilms.Methods : Materials and Methods: Here, we evaluated the effect of Au-NP against ten biofilms of Streptococcus mutans and Candida albicans isolated from patients with stomatitis. The standard strain of C. albicans (ATCC ۱۰۲۳۱) and Streptococcus mutans (PTCC ۱۶۸۳) as a control were used in this study. The Au-NP were applied on mature biofilms and after ۲۴ h of treatment their antibiofilm activities were assessed by crystal violet staining. Biomass quantification was defined and according to classification, recorded no, weak, moderate and high biofilm producer the isolates.Results : Results: The data indicated that Au-NP had excellent antibiofilm activity against Streptococcus mutans, but this activity against Candida albicans was dependent on the nanoparticle concentrations used.Conclusion : Conclusion: The results of this study suggest that the Au-NP may have clinical implications in the treatment of denture stomatitis. However, further studies are needed before recommending the use of these drugs safely in clinical situations.

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Key words: Gold nanoparticles ، Candida albicans ، Streptococcus mutans ، antimicrobial effect