Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 140

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شناسه ملی سند علمی:

JR_IJBMS-24-7_010

تاریخ نمایه سازی: 19 مرداد 1400

چکیده مقاله:

Objective(s): This study aimed to determine anti-inflammatory, antioxidant, and antiapoptotic properties of urapidil (Ura) against ovarian torsion detorsion (T/D) injury in rats. Materials and Methods: ۴۰ female Wistar albino rats were grouped as sham, T/D, T/D+dimethyl sulfoxide (DMSO), T/D+Urapidil (Ura) ۰.۵ mg/kg (low dose), and T/D+Urapidil (Ura) ۵ mg/kg (high dose) groups. In treatment groups, Ura was administered intraperitoneally just before detorsion. Biochemical parameters (TAS, TOS, MDA, MPO, and SOD) and immunohistochemical (IL-۱β, TNF-α, NF-κB, LC۳B, and Caspase-۳) analyzes were performed.Results: In the T/D group, OSI and MPO levels were elevated significantly while TAS values decreased compared with the sham group. A significant difference occurred in the low dose treatment group in TAS and OSI levels compared with the T/D group. In the high dose treatment group, significant elevation in TAS but  reduction in OSI and MDA levels were observed compared with the T/D group. Immunohistochemical staining resulted in IL-۱β, TNF-α, NF-κB, LC۳B, and caspase-۳ immunopositivity in the T/D group, while Ura treatment decreased those parameters. Intensive congestion and hemorrhage were observed in the T/D group, but contrary to this, treatment groups had alleviated congestion and hemorrhage.Conclusion: These results suggest that Ura demonstrated protective effects against ovarian T/D injury via anti-oxidative, anti-inflammatory, and anti-apoptotic features. 

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نویسندگان

Mustafa GULER

Department of Physiology, Atatürk University, Faculty of Medicine, Erzurum, Turkey

Ayhan Tanyeli

Department of Physiology, Atatürk University, Faculty of Medicine, Erzurum, Turkey

Derya GUZEL ERDOGAN

Department of Physiology, Sakarya University, Faculty of Medicine, Sakarya, Turkey

Ersen Eraslan

Department of Physiology, Yozgat Bozok University, Faculty of Medicine, Yozgat, Turkey

Selim Comakli

Department of Pathology, Atatürk University, Veterinary Faculty, Erzurum, Turkey

Elif Polat

Department of Nutrition and Dietetics, Faculty of Health Sciences, Erzurum Technical University, Erzurum, Turkey

Songul DOGANAY

Department of Physiology, Sakarya University, Faculty of Medicine, Sakarya, Turkey

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