Development and Validation of UV-Spectroscopic First Order Derivative Method for Simultaneous Estimation of Rosuvastatin Calcium and Teneligliptin Hydrobromide Hydrate in Synthetic Mixture
- سال انتشار: 1400
- محل انتشار: نشریه متدهای شیمیایی، دوره: 5، شماره: 4
- کد COI اختصاصی: JR_CHM-5-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 172
نویسندگان
B.K. Mody government Pharmacy College, Government polytechnic campus, Near Ajidam, Rajkot-۳۶۰۰۳, Gujarat, India
B.K. Mody government Pharmacy College, Government polytechnic campus, Near Ajidam, Rajkot-۳۶۰۰۳, Gujarat, India
B.K. Mody government Pharmacy College, Government polytechnic campus, Near Ajidam, Rajkot-۳۶۰۰۳, Gujarat, India
B.K. Mody government Pharmacy College, Government polytechnic campus, Near Ajidam, Rajkot-۳۶۰۰۳, Gujarat, India
B.K. Mody government Pharmacy College, Government polytechnic campus, Near Ajidam, Rajkot-۳۶۰۰۳, Gujarat, India
B.K. Mody government Pharmacy College, Government polytechnic campus, Near Ajidam, Rajkot-۳۶۰۰۳, Gujarat, India
L.M. College of pharmacy, Ahmedabad-۳۸۰۰۹, Gujarat, India
چکیده
This work aimed to develop and validate a simple, accurate, precise, and reproducible spectroscopic method for simultaneous estimation of rosuvastatin calcium and teneligliptin hydrobromide hydrate by UV-Visible first-order derivative method. According to our present knowledge, no UV method was reported for combination of rosuvastatin and teneligliptin. So, in this work, it was decided to performed the first-order derivative method and it was validated as per ICH(Q۲ R۱) guideline. Rosuvastatin calcium and teneligliptin hydrobromide hydrate showed absorbance at the working wavelength of ۲۳۰.۰۳ nm (Zero crossing point of rosuvastatin calcium) and ۲۲۲.۶۶ nm (Zero crossing point of rosuvastatin calcium), respectively, using methanol as diluent. Linearity was found over the concentration range of ۱-۴۲ µg/ml for both drugs and correlation coefficients was ۰.۹۹۹۵ and ۰.۹۹۹۴, respectively. Accuracy was found between ۹۸.۹۱%-۱۰۱.۱۳% and ۹۹.۳۸%-۱۰۰.۲۵% for rosuvastatin calcium and teneligliptin hydrobromide hydrate, respectively. LOD was found to be ۰.۲۱۳µg/ml and ۰.۱۲۰ µg/ml for rosuvastatin calcium and teneligliptin hydrobromide hydrate respectively. LOQ was found to be ۰.۶۴۶ µg/ml and ۰.۳۶۴۸ µg/ml for rosuvastatin calcium and teneligliptin hydrobromide hydrate, respectively. The result revealed that the developed method is suitable for analysis of determining rosuvastatin calcium and teneligliptin hydrobromide hydrate in a binery mixture.کلیدواژه ها
Rosuvastatin calcium, Teneligliptin hydrobromide hydrate, First order derivative method, UV spectrophotometry, ICH guidelineاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.