A Cross-Immunity between SARS-CoV-۲ and MERS-CoV: Interest in Anti-SARS-CoV-۲ Serotherapy Development Using Dromedary Serum
عنوان مقاله: A Cross-Immunity between SARS-CoV-۲ and MERS-CoV: Interest in Anti-SARS-CoV-۲ Serotherapy Development Using Dromedary Serum
شناسه ملی مقاله: JR_IEM-7-2_007
منتشر شده در در سال 1400
شناسه ملی مقاله: JR_IEM-7-2_007
منتشر شده در در سال 1400
مشخصات نویسندگان مقاله:
Abdeslam Jaafari - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Souad Lekchiri - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Hafida Zahir - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Mostafa Ellouali - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Abdallah Badou - ۲. Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco
Hassane Latrache - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
خلاصه مقاله:
Abdeslam Jaafari - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Souad Lekchiri - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Hafida Zahir - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Mostafa Ellouali - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Abdallah Badou - ۲. Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco
Hassane Latrache - ۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
Backgrounds: A potential cross-immunity between SARS-CoV-۲ and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-۲ using dromedary camel anti MERS-CoV serum.
Materials & Methods: Epidemiological and ۶۶ literature data, of which ۳۵ have been published during ۲۰۱۵-۲۰۲۱, and findings were analysed.
Findings: According to the statistical data reported during COVID-۱۹ pandemic, there are less cases and deaths associated with COVID-۱۹ in countries known for dromedary breeding and the circulation of MERS-CoV (another betacoronavirus disease transmitted by dromedary camels) among humans and dromedaries. This observation and the similarity in genome and immunopathogenicity between SARS-CoV-۲ and MERS-CoV, suggest that individuals who have been in contact with MERS-CoV infected dromedaries and/or consumed their products (milk, meat, urine) might have acquired an immunity protecting them against SARS-CoV-۲. In addition to neutralizing antibodies, this immunity could also be due to complement proteins, chemokines, and especially antimicrobial peptides (AMP), known for their effect on enveloped viruses.
Conclusion: Most research has focused on vaccines as a solution to stop the pandemic, while serotherapy hasn’t significantly aroused the interest of researchers. This potential cross-immunity between SARS-CoV-۲ and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-۲ using dromedary camel anti MERS-CoV serum.
کلمات کلیدی: SARS-CoV-۲, MERS-CoV, Cross-immunity, Serotherapy
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1245313/