A Cross-Immunity between SARS-CoV-۲ and MERS-CoV: Interest in Anti-SARS-CoV-۲ Serotherapy Development Using Dromedary Serum
- سال انتشار: 1400
- محل انتشار: فصلنامه عفونت، اپیدمیولوژی و پزشکی، دوره: 7، شماره: 2
- کد COI اختصاصی: JR_IEM-7-2_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 226
نویسندگان
۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
۲. Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco
۱. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: ۵۲۳, BeniMellal, ۲۳۰۰۰, Morocco
چکیده
Backgrounds: A potential cross-immunity between SARS-CoV-۲ and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-۲ using dromedary camel anti MERS-CoV serum. Materials & Methods: Epidemiological and ۶۶ literature data, of which ۳۵ have been published during ۲۰۱۵-۲۰۲۱, and findings were analysed. Findings: According to the statistical data reported during COVID-۱۹ pandemic, there are less cases and deaths associated with COVID-۱۹ in countries known for dromedary breeding and the circulation of MERS-CoV (another betacoronavirus disease transmitted by dromedary camels) among humans and dromedaries. This observation and the similarity in genome and immunopathogenicity between SARS-CoV-۲ and MERS-CoV, suggest that individuals who have been in contact with MERS-CoV infected dromedaries and/or consumed their products (milk, meat, urine) might have acquired an immunity protecting them against SARS-CoV-۲. In addition to neutralizing antibodies, this immunity could also be due to complement proteins, chemokines, and especially antimicrobial peptides (AMP), known for their effect on enveloped viruses. Conclusion: Most research has focused on vaccines as a solution to stop the pandemic, while serotherapy hasn’t significantly aroused the interest of researchers. This potential cross-immunity between SARS-CoV-۲ and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-۲ using dromedary camel anti MERS-CoV serum.کلیدواژه ها
SARS-CoV-۲, MERS-CoV, Cross-immunity, Serotherapyاطلاعات بیشتر در مورد COI
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