Tetracycline Resistance Associated with tet Genes or Integrons among Enterobacter cloacae Strains Isolated from Patients with Urinary Tract Infections
- سال انتشار: 1399
- محل انتشار: فصلنامه عفونت، اپیدمیولوژی و پزشکی، دوره: 6، شماره: 1
- کد COI اختصاصی: JR_IEM-6-1_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 372
نویسندگان
MSc, Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran- Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch,
PhD, Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran- Department of Infectious Diseases, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
MSc, Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
MSc, Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
چکیده
Background: This study aimed to evaluate the prevalence of tet genes and Class I and ۲ integrons in Enterobacter cloacae strains isolated from patients with urinary tract infections (UTIs).Materials & Method: A total of ۵۰ E. cloacae isolates were collected. Antimicrobial susceptibility pattern and tetracycline MIC were determined. The presence of tet genes (tetA, tetB, tetC, tetD) and Class ۱ and ۲ integrons and the content of Class ۱ integron were determined.Findings: Tetracycline MIC pattern classified ۳۶ % of the E. cloacae isolates as resistant. The most common tet gene was tetC (۲۲%), followed by tetD, tetA, and tetB. Class ۱ integron was detected in ۶۴% of the isolates. Class ۱ integron content analysis showed two variable gene cassettes (aadA۱ and aadA۵/dfrA۱۷ genes). The frequency of aadA۵/dfrA۱۷ was ۱۸.۷۵%, which was more common than aadA۱ gene (۶.۲۵%).Conclusion: The most important genetic markers for tetracycline resistance in E. cloacae isolates were tetC and Class ۱ integron. Harboring Class ۱ integron and resistance to streptomycin and ciprofloxacin were significantly correlated.کلیدواژه ها
Integron, Enterobacter cloacae, Tetracycline resistance genes, Urine, Integron content, Class ۱ and ۲ integronsمقالات مرتبط جدید
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