Comparison of pregnancy outcome in intrauterine insemination-candidate women with and without endometrial scratch injury: An RCT

Background: Endometrial scratch injury is considered controversial in increasing the success rate of assisted reproductive technology. Objective: To compare the pregnancy outcomes in women candidated for intrauterine insemination with and without an endometrial scratch. Materials and Methods: In this randomized clinical trial, ۱۵۰ women referred to the Fatemieh Hospital, Hamadan, Iran who were candidates for IUI between December ۲۰۱۷ to December ۲۰۱۸ were randomly assigned into two groups (n = ۷۵/each) with or without an endometrial scratch (as case and control groups, respectively). Women in both groups were in the proper and identical protocol for IUI. Chemical and clinical pregnancy, abortion, and live birth rate, also pregnancy complications were compared between the groups. Results: Chemical and clinical pregnancy rates were higher in the case than the control group (p = ۰.۲۵, p = ۰.۵۴, respectively). In the case group, the abortion and multiple gestation rates were ۱۴.۳% and ۴.۳%, respectively, while it was ۵% in the control group (p = ۰.۶۰, p = ۰.۵۴ respectively). The endometrium thickness on day ۲۱ was higher in the case group than the control (p = ۰.۰۱). Conclusion: Endometrial scratching in intrauterine insemination women is not associated with an increase in both clinical and clinical pregnancy rates, however, studies with a larger sample size are suggested to evaluate this intervention.

کلیدواژه ها:

Pregnancy infertility ، Women ، Endometrial injury ، Pregnancy ، Intrauterine insemination. ، خراش آندومتر ، تزریق درون رحمی اسپرم ، حاملگی.