Malignant phyllodes Tumor of the Breast; Presentation of an Uncommon Case and Review of the Literature

  • سال انتشار: 1399
  • محل انتشار: فصلنامه سرطان پستان، دوره: 7، شماره: 2
  • کد COI اختصاصی: JR_ARCHB-7-2_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 147
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نویسندگان

Sumaiya Iqbal

Department of Obstetrics and Gynecology, Latifa Women and Children's Hospital, Dubai, UAE

Juwairiyan Iqbal

Medical Education, Dubai Medical University, Dubai, UAE

Nowfala Nowshad

Department of Obstetrics and Gynecology, Latifa Women and Children's Hospital, Dubai, UAE

Khadeeje Mohammad

Department of Obstetrics and Gynecology, Latifa Women and Children's Hospital, Dubai, UAE

چکیده

Background: Phyllodes tumours are rare fibroepithelial neoplasm ofconnective tissue of the breast accounting for ۰.۳-۱% of all breast tumours with۱۰% of them being malignant. They resemble fibroadenomas clinically and can bemistakenly ignored.Case presentation: A ۳۸-year-old unmarried Philipino lady presented to theprimary health center with a mass in the right breast for the past year. Over thepreceding ۶ months, it had progressively increased in size and pain. Onexamination, a ۵ x ۳ cm firm and lobulated mass was palpated in the right upperouter quadrant. Ultrasound scan showed a solid ۴.۲۵ x ۳.۳ x ۲.۴ cm mass withheterogeneous mixed echopattern. She was referred to Surgery department wherean ultrasound-guided core biopsy showed a lesion suspicious for benign phyllodestumor. An excision biopsy revealed three foci of malignant Phyllodes on thebackground of fibroadenoma. A staging CT was performed which showed noevidence of lymph node involvement or distant metastasis. A simple mastectomywas performed and histopathology confirmed the diagnosis of malignantphyllodes tumor. Postoperatively, the patient is on regular follow up in the breastclinic and physiotherapy department. Conclusion: Phyllodes tumor bears specific clinical characteristics and shouldbe considered as a differential diagnosis in any mass lesion of the breast..Diagnosis and management are crucial in phyllodes tumor because of theirmalignant potential recurrence. Clinicians should be competent in distinguishingbetween fibroadenoma and a phyllodes tumor. Lastly, given the rarity of phyllodestumors, there is a need to establish guidelines to incorporate regular follow up forearly detection of distant metastasis.

کلیدواژه ها

Breast cancer, phyllodes tumor, malignancies

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