The effects of Urtica dioica extract on lipid profile, insulin resistance index and liver histology in polycystic ovary syndrome-induced Wistar rats

Background and aims: Urtica dioica as a medicinal herb due to its anti-inflammatory, antioxidant and hypoglycemic effects, improve type ۲ diabetes and decrease inflammation, fibrosis and necrosis as the signs of Nonalcoholic steatohepatitis. Polycystic Ovary Syndrome (PCOS) as the most important factor of infertility has an overlap of ۳۰ % to ۶۰% with liver disorders. Hence, the Urtica dioica moderator effect on liver function in PCOS rats was examined. Methods: In this experimental study ۱۴۴ adult Wistar rats were divided into control, PCOS and nettle-treated groups. The group PCOS was injected subcutaneously ۲ mg estradiol valerate, after ۶۰ days and confirmed polycystic, the experimental group was injected intraperitoneally the Urtica dioica extract doses (۱۵۰,۲۵۰, ۴۵۰ mg/kg BW). After ۲۱ days, rats were anesthetized by chloroform; blood samples and livers were collected for histological and serological evaluation. Data were analyzed using instat۳ via ANOVA one-way and p

کلیدواژه ها:

Urtica dioica ، Polycystic Ovary Syndrome ، Liver ، Necrosis ، Insulin resistance