The Relationship Between Serum Vitamin D Level and Systemic Lupus Erythematosus Activity

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 276

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شناسه ملی سند علمی:

JR_INJER-7-1_001

تاریخ نمایه سازی: 10 خرداد 1400

چکیده مقاله:

AbstractBackground and aims: : Systemic lupus erythematosus (SLE) is an autoimmune disease which involvesvarious organs. Vitamin D is an essential ingredient in regulating the immune system. This study aimedto investigate the relationship between vitamin D and the severity of lupus activity.Materials and Methods: This case-control study was carried out on ۳۸ patients with lupus on the basisof the American College of Rheumatology (ACR) criteria and ۴۴ healthy subjects with no history ofrheumatologic disease. To measure the level of ۲۵-hydroxy vitamin D, venous blood samples (۵ cc)were taken from each participant and the activity of the lupus disease was measured by the SystemicLupus Erythematosus Disease Activity Index (SLEDAI) scale. Finally, the chi-square test, independentsample t test, one-way ANOVA, and multiple linear regression analysis were used to measuremultivariate effects. The level of significance was set to be P < ۰.۰۵.Results: Thirty-five lupus patients and ۴۰ healthy subjects were females (P = ۰.۸۴۷). Vitamin Ddeficiency was observed in the case (۴۲.۱%) and control (۱۱.۴%) groups. The mean value of serumvitamin D۳ level was ۳۵.۳ ng/mL in the control group, as well as ۲۴.۶ ng/mL and ۲۱.۳ ng/mL inpatients with mild and severe SLE, respectively (P = ۰.۰۲۴).Conclusion: In this study, high levels of ۲۵-hydroxy vitamin D were observed among the healthysubjects compared to patients with SLE. Eventually, the level of vitamin D significantly decreased byincreasing the severity of SLE activity.

نویسندگان

Batool Zamani

Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Hossein Akbari

Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, Iran

Mehrdad Mahdian

Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran

Ehsan Dadgostar

Halal Research Centers of IRI, FDA, Tehran, Iran