Association of C۶۷۷T Single Nucleotide Polymorphism of MTHFR with Susceptibility to Autism Spectrum Disorders

  • سال انتشار: 1400
  • محل انتشار: فصلنامه پزشکی شخصی، دوره: 5، شماره: 20
  • کد COI اختصاصی: JR_PMJ-5-20_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 273
دانلود فایل این مقاله

نویسندگان

Neda Mousavi-Niri

Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Mohammad Ali Saremi

Personalized Medicine Research Center of AmitisGen, Tehran, Iran

چکیده

In general, people with Autism Spectrum Disorders (ASD) have problems in social, emotional, and communication skills. Genome-Wide Association Studies (GWAS) have suggested a potential association of the C۶۷۷T polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) with autism spectrum disorders. The present study intended to investigate the relationship between this polymorphism of MTHFR and the severity of autism symptoms in two groups of children affected by autism and healthy children to elucidate its potential role as a risk factor for ASD. study included ۴۰ patients with autism and ۴۰ healthy participants with matched age as control. The samples from the participants underwent ARMS-PCR for MTHFR genotyping.   The CC genotype was reported in ۵۰% (n=۲۰) and ۷۲.۵۰% (n=۲۹) of the children in the study and control groups, respectively, while the CT genotype was observed in ۳۵% (n=۱۴) of the study group and ۱۷.۵۰% (n=۷) of the control group. Also, ۱۵% (n=۶) of the study group and ۱۰% (n=۴) of the control group had the TT genotype. According to our results, the genotype distribution and allele prevalence were significantly different between the groups.

کلیدواژه ها

Autism, MTHFR, ARMS-PCR, Genetic

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.