The effect of Iranian capripoxvirus vaccine strains on neutralizing antibody titer in cattle
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 205
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شناسه ملی سند علمی:
JR_IJVST-12-2_011
تاریخ نمایه سازی: 21 اردیبهشت 1400
چکیده مقاله:
Lumpy skin disease (LSD) virus, Goat-poxvirus (GPV), and Sheep-poxvirus (SPV) are members of genus capripoxvirus (CaPV) and have close genetic similarity. The use of CaPV-vaccine strains would be useful to protect the cattle against LSD. This study aimed to compare the neutralizing antibody titer of Iranian heterologous sheep pox and goat pox vaccines against LSD in cattle. A total of ۱۰۰ calves was vaccinated with Gorgan-GPV and Ramyar-SPV vaccines on separate farms. Neutralizing antibody titer and side effects of vaccines were evaluated at days ۱۴, ۲۸, ۴۵, ۹۰, and ۱۸۰ post-vaccination. The mean of rectal temperature in SPV was higher than GPV and persisted for up to ۳ days. Also during the onset time of fever, ocular and nasal discharge were observed, whereas in the GPV and control group no clinical signs were observed. In each vaccinated group, the first detectable antibody titer was after ۱۴ days and rose to peak at ۲۸-۴۵ days post-vaccination, then it decreased in the following days. Although, the mean of the neutralizing index (NI) titer between GPV and SPV was relatively similar and there was no statistically significant difference (p > ۰.۰۵) at all days of the experiment, but in GPV the titer appeared slightly higher than SPV and reached to protective level (NI ≥ ۱.۵) on day ۴۵ post-vaccination. There was a high antibody titer (Log۱۰۱.۰۷) in the day ۱۸۰ post-vaccination. The results showed that GPV vaccine because of the induction of the protective level of antibody titer, and persisting within a long period for up to ۱۸۰ day post-vaccination, has a good immunogenic response, so is considered a suitable vaccine to control LSD.
کلیدواژه ها:
نویسندگان
حامد عیسی پور
Resident of large animal internal medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
مهدی سخا
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
حمید رضا ورشوی
Department of Animal Viral Vaccines, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
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