The meaningful change in Antibiotic-resistant gene expression of Staphylococcus aureus by using functionalized carbon nanotubes Nanofluid
- سال انتشار: 1399
- محل انتشار: چهارمین کنگره بین المللی و شانزدهمین کنگره ملی ژنتیک
- کد COI اختصاصی: CIGS16_321
- زبان مقاله: انگلیسی
- تعداد مشاهده: 247
نویسندگان
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
چکیده
Background and Aim: Staphylococcus aureus is a gram-positive bacterium and has been considered as an important nosocomial pathogen universal owing to its increasing antibiotic resistance and carries the Tet (M) gene encoding a tetracycline efflux pump. Recently, Carbon nanotubes have defined as novel and potential antibacterial and Nanocarrier agents. Aim: In this investigation, Antimicrobial effects study of carbon nanotubes Nanofluid on Staphylococcus aureus and gene expression study on the Tet (M) gene done.Methods: Cell viability assay was carried out after incubation of Staphylococcus aureus by the CNT's suspensions (۱۰۰ µg /ml) and antibiotic for ۲۴, ۴۸, and ۷۲ h. Then the gene expression profile of the Tet (M) gene was studied by Real-Time PCR method on bacteria, which were treated by functionalized carbon nanotubes Nano fluid+ Antibiotic in comparison with Antibiotic alone.Results: Results were conferred significantly, reduced bacterial proliferation, and reduced expression of the Tet (M) gene in the Nano fluid+ Antibiotic condition.Conclusion: The present study showed that the functionalized carbon nanotubes Nanofluid could be a proper drug delivery vehicle for overcoming bacterial Antibiotic-resistant.کلیدواژه ها
Antibiotic-resistant, Staphylococcus aureus, Carbon nanotubes, Nanofluid, Tet (M) gene.مقالات مرتبط جدید
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