Long non-coding RNA H۱۹ in bipolar disorder

Background and Aim: Bipolar disorder is a type of serious mental disorder that is high in prevalence and associated with other common psychiatric disorders. Mitochondrial dysfunction and oxidative stress that initiate cell death is one of the pathways involved in this disorder. The diagnosis of bipolar disorder remains difficult. Some lncRNAs control oxidative stress and can be used as biomarkers. lncRNA H۱۹ is one of the lncRNAs that regulate cellular stress and has a regulatory role in cell fate and differentiation. Studies have shown that lncRNA H۱۹ is expressed in hippocampal neurons and promotes apoptosis in these neurons. In the current study, we evaluated expression levels of lncRNA H۱۹ in the bipolar disorder (BD) patients and healthy subjects.Methods: The levels of lncRNA H۱۹ was tested in peripheral blood mononuclear cells (PBMCs) of ۵۰ BD and ۵۰ controls by real-time PCR.Results: Our data demonstrated that transcript levels of lncRNA H۱۹ significant difference in BP patients compared with controls.Conclusion: Our results revealed that the transcript levels of lncRNA H۱۹ could be considered in neuropathobiology of bipolar disorder and as a good putative biomarker for individuals with bipolar disorder.

کلیدواژه ها:

Bipolar disorder ، lncRNA H۱۹ ، long non coding RNAs ، biomarker