Association of SOCS۱ -۱۴۷۸ CA/del polymorphism with coronary artery disease
- سال انتشار: 1399
- محل انتشار: چهارمین کنگره بین المللی و شانزدهمین کنگره ملی ژنتیک
- کد COI اختصاصی: CIGS16_212
- زبان مقاله: انگلیسی
- تعداد مشاهده: 311
نویسندگان
MSc Student in Genetics - University of Guilan
University of Guilan - Department of biology
Guilan university of medical sciences
چکیده
Background and Aim: Coronary artery disease is the leading global cause of mortality. Coronary artery disease (CAD) means decrease in blood flow to heart muscles due to formation of atherosclerotic plaques. This happens when cholesterol and other substances gather in plaque form. Acute clinical events, such as acute myocardial infarction (MI), unstable angina, ventricular fibrillation, or sudden coronary death are generally due to plaque destabilization and thrombosis ۱. CAD has some well-known risk factors such as high blood pressure, diabetes, obesity, High blood cholesterol, smoking, alcoholism, low activity, and genetic factors ۲. The ۹p۲۱ locus is the most studied sequence that is related to CAD. Variants of LDL-R, PCSK۹, and APOB genes that are correlated with hypercholesteremia, are also known to have a role in CAD. Recent studies show that inflammations have significant role in formation of atherosclerosis and CAD by mediation of cytokines and inflammatory cells. One of the most important pathways in inflammatory processes is JAK/STAT signaling pathway. SOCS۱, a protein coding gene on ۱۶p۱۳.۱۳ locus, can block this pathway and suppress the secreted cytokines’ activity. SOCS۱ protein is a negative inhibitor of cytokines and can be activated by the same cytokines. It is known that higher amount of gene expression in SOCS۱ can lead to a decrease in inflammatory response and prevents progression of atherosclerotic plaque.Methods: Blood samples of CAD and control groups were collected from patients who referred to Heshmat Hospital (in Rasht) with chest pain. DNA Extracted from samples and propagated using ARMS-PCR method and the results were analyzed with MedCalc and SPSS software.Results: The CA/del genotype frequency in Control group was significantly higher than CAD group.This study shows there is a strong association with this deletion and lower risk of CAD.Conclusion: This study suggests that the SOCS۱ -۱۴۷۸ CA/del polymorphism is a possible genetic determinant for the risk of CAD. The observation shows that this polymorphism decreases the risk of CAD. Though more association studies are absolutely needed.کلیدواژه ها
CAD, SOCS۱, Polymorphism, Atherosclerosisمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.