Shervin Afzali - Department of Cellular and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C, Tehran, Iran
Shirin Farivar - Department of Cellular and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C, Tehran, Iran

Background and Aim: Unlimited mitosis is the main fact behind the concept of cancer cell proliferation. To be capable of controlling abnormal cell proliferation is of great value and enable us to fight the most lethal disease that has caused death over the past decade. Disruption of the mitotic division process makes the tumor cells undergo mitotic arrest. Generally, it is followed by the death of the above-mentioned cells. Antimitotic therapy has been identified as an effective and essential way of treating cancer. It is noteworthy that there are several libraries in which lots of anti-mitotic agents are introduced for further scientific research but their exact mechanisms are yet to be identified. In order to apprehend the antitumor mechanism of such chemicals, one bioactive compound, MT۷, has been chosen as a model. In previous research which was done by Zhang et al., Microarrays results of HeLa cells in a time period of MT۷ treatment were published. The gene expression profiles were further analyzed by Functional Protein Association Networks.Methods: A dataset containing ۵ samples was retrieved from NCBI and its heat map was drawn. Firstly, the part of the heat map which has the highest contrast between the control sample and ۱۲ hours treated one was selected, and ۱۳۹۸ corresponding genes were analyzed in the String package and their Functional Protein Association Networks were retrieved.Results: Cell proliferating limitation which was the result of treating cancer cell culture by MT۷ has a notable impact on endometrial cancer. ۱۰ of ۵۸ gene sets related to endometrial cancer were activated by MT۷ and head a great contribution to it.Conclusion: By and large, MT۷ restricts cancer cells’ division in several mechanisms. As it was discovered before, it makes cancer cells undergo mitotic arrest. By analyzing the network which was mentioned before, it seems that it also has a major impact on endometrial cancer. That may have inhibitory effects on endometrial cancer and can be exploited as a means of disease suppression.

endometrial cancer, MT۷, mitotic arrest