۱۸F-THK ۵۳۵۱ and ۱۱C-PiB PET of the Thai normal brain template

Objective(s): The aim of the study was to create a local normal database brain template of Thai individuals for ۱۱C-Pittsburgh compound B (۱۱C-PiB) and ۱۸F-THK ۵۳۵۱ depositions using statistical parametric mapping (SPM) software, and to validate and optimize the established specific brain template for use in clinical practice with a highly reliability and reproducibility. Methods: This prospective study was conducted in ۲۴ healthy right-handed volunteers (۱۳ men, ۱۱ women; aged: ۴۲–۷۹ years) who underwent ۱۸F-THK ۵۳۵۱ and ۱۱C-PiB PET/CT scans. SPM was used for the ۱۸F-THK ۵۳۵۱ and ۱۱C-PiB PET/CT image analysis. All PET images were processed individually using Diffusion Tensor Image -Magnetic Resonance Imaging-weighted images (DTI-MRI images), which involved: (۱) conversion of Digital Imaging and Communications in Medicine (DICOM) files into an analyzable file extension (.NIFTI) for statistical parametric mapping, (۲) setting of the origin (the anterior commissure was used as the anatomical landmark), (۳) re-alignment, (۴) co-registration of PET with B۰ (T۱W) and DTI-MRI images, (۵) normalization, and (۶) normal verification using the Thai MRI standard. We then compared the normal PET template with the abnormal deposition area of different dementia syndromes, including Alzheimer’s disease and progressive supranuclear palsy. Results: This method was able to differentiate cognitively normal from Alzheimer’s disease and progressive supranuclear palsy subjects . Conclusions: This normal brain template was able to be integrated into clinical practice and research using PET analyses at our center.

کلیدواژه ها:

brain template ، amyloid ، Tau protein