Effect of ۸ weeks Aerobic Training and Nigella Supplement on Insulin Resistance, Lipid Profile and Plasma Level of HbA۱c in Type ۲ Diabetic Rats
- سال انتشار: 1397
- محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 27، شماره: 120
- کد COI اختصاصی: JR_ZUMS-27-120_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 178
نویسندگان
Dept. of Sport Sciences,Faculty of Human Sciences, University of Maragheh, Maragheh, Iran
Dept. of Physical Education and Sport Sciences, Faculty of Human Sciences, Urmia University, Urmia, Iran
چکیده
Background and Objective: Metabolic syndrome is defined as a cluster of metabolic disorders, which may lead to type II diabetes and cardiovascular diseases. The aim of this study was to investigate the effect of ۸ weeks of aerobic training and Nigella sativa supplements on insulin resistance, lipid profiles, and plasma levels of HbA۱c in Type ۲ diabetic rats. Materials and Methods: ۳۵ male Wistar rats were divided into five groups. Diabetes was induced by intraperitoneal injection of streptozotocin. The training program included ۸ weeks of aerobic training on a treadmill. The supplement group consumed N. Sativa supplement at the end of each training session at the dose of ۴۰۰mg/kg/day. After ۸ weeks of aerobic training and N.Sativa consumption, the plasma levels of HbA۱C, insulin resistance and lipid profiles were measured. Results: The results showed that blood glucose level in all three groups was significantly lower than the baseline (P=۰.۰۰۰۱). Cholesterol, triglyceride and LDL showed the most significant decrease in aerobic and combination training groups (P=۰.۰۰۰۱). In HDL index, aerobic and combined exercise groups showed a significant increase (P=۰.۰۰۰۱). Hemoglobin A۱c index and insulin resistance in the combination group showed a significant decrease compared to the other groups (P=۰.۰۰۰۱). Conclusion: The results show that exercise along with N. Sativa supplement is more effective than N. sativa supplement or exercise alone in the status of rats with type ۲ diabetes. This kind of combination therapy may also be applicable to diabetic patients.کلیدواژه ها
Diabetes, Aerobic Training, Nigella, Insulin resistanceاطلاعات بیشتر در مورد COI
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