Prevalence of Toxoplasmosis in Dialysis Patients
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 202
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شناسه ملی سند علمی:
JR_ZUMS-25-112_011
تاریخ نمایه سازی: 11 اردیبهشت 1400
چکیده مقاله:
Background and Objective: Toxoplasma gondii is one of the most important opportunistic parasites and can lead to acute toxoplasmosis in immunocompromised patients. Due to the specific conditions of dialysis patients, this parasite may have different clinical features when compared to other individuals. Given the vulnerability of these patients and lack of information on this subject in Zanjan and Mazandaran, this study was performed on dialysis patients in these two provinces.
Materials and Methods: ۲۸۰ patients with renal failure undergoing hemodialysis were studied. Their personal information was recorded with questionnaires while blood samples were collected and sera were isolated and subjected to anti-Toxoplasma antibody evaluation using ELISA technique.
Results: The patients included ۱۵۶ men (۵۵.۷%) and ۱۲۴ women (۴۴.۳%). Anti-Toxoplasma IgG was positive in ۲۳۲ patients (۸۲.۹%). The sero-positive ratio of patients in Mazandaran was higher than that of Zanjan (P <۰.۰۵). There was no significant association between infection rate and other variables such as location of residence, duration of dialysis, age and gender. Anti-Toxoplasma IgM, indicative of possible acute toxoplasmosis, was also detected in ۱۶ patients (۵.۷%), all of whom were men from the Mazandaran province.
Conclusion: The study showed that Toxoplasma seroprevalence (indicative of parasite existence in their body) in patients undergoing hemodialysis in the study areas is high. Considering the particular circumstances of dialysis patients and the possibility of reactivation of this parasite from its chronic phase to its acute phase, regular screening for anti-Toxoplasma antibodies in this group of patients is recommended.
کلیدواژه ها:
نویسندگان
فرزانه جعفریان
Dept. of Parasitology and Mycology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
سلمان غفاری
Dept. of Medical Parasitology and Mycology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
روجا جعفریان
دانشگاه علوم پزشکی شهید بهشتی، تهران
اصغر فضائلی
Dept. of Parasitology and Mycology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
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