The Effect of Prolonged Oral Administration of Silybum Marianum (SM) Shoots on Learning and Memory in Streptozotocin induced-Diabetic Rats.
- سال انتشار: 1386
- محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 15، شماره: 59
- کد COI اختصاصی: JR_ZUMS-15-59_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 166
نویسندگان
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
چکیده
Background and Objective: Diabetes mellitus (DM) especially type A, is accompanied by disturbances in learning, memory, and cognitive skills in human society and experimental animals. Regarding the beneficial effect of SM on lipid peroxidation in hyperlipidemia and on serum lipids in DM, this study was conducted to evaluate the effect of prolonged oral administration of SM on learning and memory in diabetic rats. Materials and Methods: Female wistar rats (n = ۳۶) were randomly divided into control, SM-treated control, diabetic, and SM-treated diabetic groups. Treatment groups received a mixture of SM and standard rat food at a weight ratio of ۶.۲۵% for ۴ weeks.To induce diabetes, streptozotocin was injected intraperitoneally at a single dose of ۶۰ mg/kg. For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of the study using passive avoidance test. Meanwhile, alternation behavior percentage was determined using Y maze test. Results: There was a significant increase (p = ۰.۰۳۲) in IL in diabetic and SM-treated diabetic groups after ۴ weeks compared to control group. There was no significant difference between diabetic and SM-treated diabetic groups. On the other hand, STL decreased significantly (p = ۰.۰۳۲) in diabetic group while it increased significantly (p = ۰.۰۲۷) in SM-treated group compared to control group at the end of the study. The results of Y maze showed that alternation score was not different between treated and untreated diabetic groups. Conclusion: SM could enhance the consolidation and recall capability of stored information but did not affect spatial memory of diabetic animals.کلیدواژه ها
Silybum marianum, Learning, Memory, Passive avoidance Test, Diabetes mellitusاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.